Clinical Trial - osteosarcoma

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Clinic Seeks Dogs with Appendicular Osteosarcoma for Trial
The University of Illinois Cancer Care Clinic recently secured resources to initiate a funded clinical trial involving osteosarcoma (OSA), by far the most common primary bone tumor in dogs. The main goal of this trial is to objectively assess the effectiveness of aminobisphosphonates for the management of bone pain associated with canine appendicular OSA. Aminobisphosphonates have been used effectively in humans for more than 10 years, and our Cancer Care Clinic has been safely using them in dogs since 1996.

Dogs with appendicular OSA meeting study inclusion criteria will be provided FREE aminobisphosphonate every 28 days for palliative therapy of bone pain. (The normal cost of this aminobisphosphonate is fairly expensive: for a dog weighing greater than 75 pounds, it would be approximately $600/dog/treatment.) The provision of up to three doses of aminobisphosphonate at no cost may serve as a significant financial incentive. Additionally, owners will be compensated in the amount of $300 when returning for the first monthly scheduled recheck appointment.

Background on Treatment of OSA:
It is estimated that over 8,000 dogs per year will be diagnosed with OSA in the United States. Canine patients diagnosed with OSA are often middle-aged to older dogs of large or giant body size, with definite over-representation of certain breeds such as the Rottweiler, Saint Bernard, Golden retriever, Irish wolfhound, and Greyhound. Conventional standard therapy for canine appendicular OSA includes amputation of the affected limb, and administration of adjuvant chemotherapy.

A fair number of patients may be poor candidates for amputation, due to complicating factors such as severe degenerative joint disease, significant obesity, and multiple tumor sites, or because of owner reluctance for this radical procedure. Therefore, other means to effectively control local bone pain, and possibly halt or slow the progression of the primary bone tumor growth, should be investigated. While pain management is recommended through the use of non-steroidal anti-inflammatory drugs (NSAIDs) and opioids, these analgesic agents usually do not provide adequate pain control in dogs with advanced osteolytic diseases, including OSA.

Although palliative radiation therapy has proven to be effective in significantly decreasing bone pain in 75 to 80 percent of dogs with OSA, this form of therapy is not readily available everywhere, and can be relatively expensive. In the past decade, human beings suffering from painful bone cancers have demonstrated a survival advantage, and benefited from significant pain reduction, when treated with a class of potent antiresorptive agents known as aminobisphosphonates.

Contact Information:
For a more detailed description of the Funded Clinical Trial for Appendicular Osteosarcoma, please contact the following individuals at the University of Illinois Veterinary Teaching Hospital:

Timothy M. Fan, DVM
(217) 333-5375 Louis-Philippe de Lorimier, DVM
(217) 265-4088 Sarah Charney, DVM
(217) 244-8747




College of Veterinary Medicine University of Illinois
Veterinary Teaching Hospital, Weekdays 8:30 am to 6:30 pm
Large Animal Clinic 1102 West Hazelwood Drive 217/333-2000
Small Animal Clinic 1008 West Hazelwood Drive 217/333-5300
Urbana, IL 61802
Small Animal Clinic Appointment Hotline, 217/265-5163, 8:30 am to 4:30 pm