When did she have the flagyl?????
Don't know if this is pertinant or not but just read this:
Putative Metronidazole Neurotoxicosis in a Cat -- Olson et al. 42 (5): 665 -- Veterinary Pathology
In dogs and cats, central vestibular and cerebellar dysfunctions resulting in ataxia, nystagmus, head tilt, tremors, and
seizures are commonly reported in cases of metronidazole toxicosis
There are relatively few publications addressing the mechanism of metronidazole neurotoxicity. It is thought that the intermediate metabolites of metronidazole are able to bind to and disrupt cellular deoxyribonucleic acid (DNA) and induce cell death in anaerobic microorganisms.3,25
In mammalian cells, it has been proposed that metronidazole and/or its metabolites may bind to ribonucleic acid (RNA) instead of DNA.3,4,14 This RNA binding may inhibit RNA and/or protein synthesis, potentially leading to axonal degeneration.3,4,14,25 Using a rodent auditory model, investigators have also demonstrated that the severity of the lesions associated with metronidazole toxicity may be modulated by the level of functional brain activity (neurons).18 In humans, reversible changes have been observed in the brains of patients with metronidazole-induced encephalopathy by magnetic resonance imaging. Ahmed et al.1 suggested that the reversible changes associated with the acute toxic effects of metronidazole are most likely due to axonal swelling with increased water content rather than due to a demyelinating process. Another proposed mechanism involves vascular spasm that could produce mild reversible localized ischemia.1 The mechanism of action of metronidazole neurotoxicosis also may involve the modulation of the inhibitory neurotransmitter -aminobutyric acid (GABA) receptor within the cerebellar and vestibular systems.6 In support of this hypothesis,
it has recently been demonstrated that diazepam, a benzo-diazepine with major effects on GABA neurotransmitters in the brain,
dramatically improved the recovery times for dogs with metronidazole toxicosis.6 Although most veterinary metronidazole toxicosis patients improved within 5–7 days after discontinuation of the drug,
weeks and sometimes months may be required to completely resolve the neurologic effects.10 Thus, the time course to resolution of neurologic clinical signs is variable and likely multifactorial.
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I'm also seeing chemicals in carpet (and carpet cleaners) linked to seizures as well...
just read this:
New carpets are extremely high in toxic chemicals, as are many pieces of upholstered furniture. Most types of paint are also highly toxic, as are wood preservatives.